Bridged Bicyclic Compounds and their Derivatives as Neuroprotective Agents

Description:

These novel compounds possess unique molecular features and exhibit neuroprotective effects as evidenced in Drosophila melanogaster, a fruit fly model. The compounds were also subjected to a post-synaptic transmission assay. Of the compounds tested, two compounds demonstrated potent neuroprotective properties relative to resveratrol. One of disclosed compounds provided extended time to synaptic failure by approximately 100 minutes. Another compound allowed the synapse under study to maintain 80% of its normal function even under declining oxidative conditions.

Patent Information:
For Information, Contact:
Dana Vouglitois
Florida Atlantic University
dvouglitois@fau.edu
Inventors:
Salvatore Lepore
Kenneth Dawson-scully
Elijah St. germain
Wesley Bollinger
Samantha Maki
Keywords:
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