Granulocyte Colony-Stimulating Factor (GCSF) Gene Therapy for Stroke and Alzheimer's Disease

Description:

Granulocyte colony-stimulating factor (GCSF) is a glycoprotein involved in a number of different tissues. It is responsible for the stimulation of cellular survival, proliferation, and differentiation in various cell types. This technology is a new therapeutic strategy for the stimulation of GCSF to help protect neural tissues for those with Alzheimer’s disease and stroke. Itis comprised of an adeno-associated viral (AAV) vector, a virus that can infect humans without causing disease. This specific AAV vector consists of the cytomegalovirus (CMV) promoter, which is used to induce transient transfection of a gene into a cell. The inventors have performed several experiments to demonstrate proof of concept using AAV-GCSF as a potential therapeutic in several in vitro and in vivo animal models.

Patent Information:
For Information, Contact:
Dana Vouglitois
Florida Atlantic University
dvouglitois@fau.edu
Inventors:
Jang-Yen Wu
Keywords:
© 2018. All Rights Reserved. Powered by Inteum