Granulocyte Colony-Stimulating Factor (GCSF) Gene Therapy for Stroke and Alzheimer's Disease


Granulocyte colony-stimulating factor (GCSF) is a glycoprotein involved in a number of different tissues. It is responsible for the stimulation of cellular survival, proliferation, and differentiation in various cell types. This technology is a new therapeutic strategy for the stimulation of GCSF to help protect neural tissues for those with Alzheimer’s disease and stroke. Itis comprised of an adeno-associated viral (AAV) vector, a virus that can infect humans without causing disease. This specific AAV vector consists of the cytomegalovirus (CMV) promoter, which is used to induce transient transfection of a gene into a cell. The inventors have performed several experiments to demonstrate proof of concept using AAV-GCSF as a potential therapeutic in several in vitro and in vivo animal models.

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For Information, Contact:
Dana Vouglitois
Florida Atlantic University
Jang-Yen Wu
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